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Life Sciences

Data-driven policy promoting innovation and access. 

Life Sciences

About Life Sciences

Pioneer’s Life Sciences Initiative (PLSI) is a nationally recognized authority on life sciences policy, working in Washington, D.C., and in more than 20 states. Leveraging a team of experts from around the country, PLSI strengthens the policies that drive biomedical innovation and expand patient access.  

Our work draws on extensive experience with QALY analysis, economic modeling, patent protections, FDA pathways, gene therapies, pricing and price controls, pharmacy benefit managers, out-of-pocket affordability issues, and federal drug pricing programs such as 340B.  

Informed by deep expertise in regions like Massachusetts—home to the world’s leading life sciences cluster—where industry, universities, hospitals, and nonprofits come together to advance discovery and set standards for excellence, we aim to keep the United States a global leader in developing breakthrough therapies and ensuring patients have access to them. 

June 25, 2025

Study Finds Trump’s Most Favored Nation Drug Proposal Could Still Raise Out-of-Pocket Costs Without PBM Reform

BOSTON — Out-of-pocket drug costs for seniors may rise under President Trump’s Most Favored Nation (MFN) proposal if policymakers do not address the role of pharmacy benefit managers (PBMs), according to a brief released today by the Pioneer Institute.
May 9, 2025

Pioneer Institute Launches Tracker Showing Drug Price Controls Are Raising Out-of-Pocket Costs for Medicare Patients

A new data tool from Pioneer Institute reveals that federal drug price controls—intended to reduce out-of-pocket costs for seniors—are instead making many prescription drugs more expensive for Medicare beneficiaries.  
January 23, 2025

Pioneer Institute Study Calls for Reforms to Ensure that Pharmacy Benefit Manager Practices Benefit Patients, Healthcare Payers

Congress likely to take up PBM reform early this year; Pioneer Institute Calls for PBM’s to be more transparent

An Evaluation of 340B in Massachusetts

Despite the fact that the 340B Drug Pricing Program has expanded immensely in recent years, the amount of charity care that hospitals are providing has decreased. This points to several problems with the 340B program across the country and in Massachusetts, such as a lack of transparency and inaccessible care.

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Full-Time State Employees: 2024

How big is your state government? Florida ranks last in the U.S. for full-time state government employees per 100K population — just 706 in 2024. Massachusetts had nearly double that with 1,401 per 100K. Explore the numbers: https://loom.ly/TDrajc0 #facts #stategovernmentemployees